کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4346149 | 1296774 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Catechol-O-methyltransferase (COMT) inhibition reduces spinal nociceptive activity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Several variants of the catechol-O-methyltransferase (COMT) gene have recently been linked to pain sensitivity. In the present study, electrophysiological field potential recordings from the dorsal horn in rats were used to examine the spinal effect of reduced COMT activity. The data demonstrated that 30 mg/kg of the COMT inhibitor OR 486 reduced spinal nociceptive responses to painful stimuli (p ≤ 0.01, OR 486 vs. vehicle) and attenuated the expression of spinal long-term potentiation (LTP), an often studied model for central sensitization (p ≤ 0.01, HFS vs. HFS + OR 486). Our findings suggest that low COMT activity may have an antinociceptive effect in the spinal cord.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 473, Issue 3, 12 April 2010, Pages 212–215
Journal: Neuroscience Letters - Volume 473, Issue 3, 12 April 2010, Pages 212–215
نویسندگان
Line M. Jacobsen, Guro S. Eriksen, Linda M. Pedersen, Johannes Gjerstad,