کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4346184 1296775 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The ERG responses to light stimuli of melanopsin-expressing retinal ganglion cells that are independent of rods and cones
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The ERG responses to light stimuli of melanopsin-expressing retinal ganglion cells that are independent of rods and cones
چکیده انگلیسی

The mechanisms by which melanopsin-expressing retinal ganglion cells (mRGCs) regulate circadian rhythms in humans have not been established. To understand mRGC characteristics and their role independent of effects due to the rods and cones, mRGC responses should be induced or measured independent of cone and rod responses. In the present study, we obtained results from light stimuli which differentially induce only the mRGC response by using a receptor-silent substitution technique. The mRGCs responded linearly to contrast changes of light stimuli, whereas they showed complicated responses to frequency changes with regard to the latency of response time. These results suggest that mRGC behavior is not a simple response to the various frequencies found in solar light but may be related to intrinsic neural circuits with feedback connections in the mRGC pathway. The results in this study also demonstrated that the test stimuli affected only the mRGC response and that this could be successfully detected by using the electroretinogram (ERG).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 479, Issue 3, 2 August 2010, Pages 282–286
نویسندگان
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