کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4346326 1296783 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of blood glucose level regulation in mouse opioid withdrawal models
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Characterization of blood glucose level regulation in mouse opioid withdrawal models
چکیده انگلیسی

The regulation of blood glucose level in intracerebroventricular (i.c.v.) administration with opioid alone or opioid withdrawal model was studied in ICR mice. In the first group, we found that i.c.v. administered morphine or β-endorphin alone causes an elevation of blood glucose level. Blood glucose level induced by i.c.v. morphine or β-endorphin began to increase within 30 min and reached maximal level at 1 h, decreasing to the basal level after 2 h. In another group, we observed that intraperitoneal (i.p.) injection with naloxone (10 mg/kg) post-treated 3 h after either a single i.c.v. injection with morphine or β-endorphin did not affect the increased blood glucose level in either group. In the next study, we observed that multiple (1 time/day for 3 days) i.c.v. injection with morphine alone significantly increased the blood glucose level. However, i.p. injection with naloxone post-treated 3 h after the last i.c.v. injection with morphine caused a decrease of blood glucose level. We found that multiple (1 time/day for 3 days) i.c.v. injections with β-endorphin did not affect the blood glucose level. Furthermore, i.p. injection with naloxone did not affect the blood glucose level in the mice injected with multiply β-endorphin. Our results suggest that both morphine and β-endorphin administered i.c.v. acutely increases the blood glucose level. However, blood glucose levels in the groups of multiply administered morphine alone, β-endorphin alone, and naloxone-treated withdrawal model in multiply injected morphine and β-endorphin appear to be differentially regulated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 476, Issue 3, 7 June 2010, Pages 119–122
نویسندگان
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