کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4346368 | 1296785 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TGF-β stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: TGF-β stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs) TGF-β stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs)](/preview/png/4346368.png)
چکیده انگلیسی
Dental stem cells such as dental follicle precursor cells (DFPCs) are capable of neural-like differentiation. However, compared to neuroectodermal progenitor cells such as murine retinal progenitor cells (mRPCs) they show only a limited capacity for glial cell differentiation. In this study we tested the influence of cell signaling on glial differentiation of mDFPCs. These cells were treated with inhibitors and activators of the Sonic hedgehog-, the Wnt/β-Catenin-, and the TGF-β-pathway. After incubation only an activation of the TGF-β-pathway showed a remarkable glial-like cell differentiation. In contrast gene expression of neural cell markers was not regulated. In conclusion, TGF-β improved glial-like, but not neural-like, differentiation of mDFPCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 471, Issue 3, 8 March 2010, Pages 179-184
Journal: Neuroscience Letters - Volume 471, Issue 3, 8 March 2010, Pages 179-184
نویسندگان
Oliver Felthaus, Wolfgang Ernst, Oliver Driemel, Torsten E. Reichert, Gottfried Schmalz, Christian Morsczeck,