کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4346436 1296787 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new paraneoplastic encephalomyelitis autoantibody reactive with the axon initial segment
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
A new paraneoplastic encephalomyelitis autoantibody reactive with the axon initial segment
چکیده انگلیسی
Serum from a patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer (SCLC) showed high titer immunohistochemical staining of the axon initial segment (AIS) on rat and human brain sections. EM studies showed that the antigen was localized in close proximity of the microtubules in the AIS. Double labeling experiments and absence of staining at the nodes of Ranvier excluded the previously identified βIV spectrin as autoantigen. Screening a rat hippocampal cDNA library resulted in the isolation of ubiquitin-conjugating enzyme E2E1 (UBE2E1). However, blocking and elution experiments excluded UBE2E1 as the AIS autoantigen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 467, Issue 2, 25 December 2009, Pages 169-172
نویسندگان
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