کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4346524 | 1296792 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Improvement of auditory discrimination learning by Ginkgo biloba extract EGb 761®
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The effect of oral application of Ginkgo biloba extract EGb 761® on auditory discrimination learning in Mongolian gerbils was investigated using discrimination tasks with three different degrees of difficulty and two protocols for administration starting 2 weeks prior to or at the beginning of training. In comparison to placebo-treated controls we observed significant improvement of learning performance in EGb 761® treated gerbils in discrimination tasks of all degrees of difficulty, from the easiest to the most demanding. EGb 761® has been reported to increase the extracellular concentration of dopamine in prefrontal cortex of rats which plays a major role in the type of discrimination learning used in the present study. We, therefore, suppose that EGb 761® improves discrimination learning through its effect on the dopaminergic system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 463, Issue 3, 9 October 2009, Pages 219-222
Journal: Neuroscience Letters - Volume 463, Issue 3, 9 October 2009, Pages 219-222
نویسندگان
Christoph K. Moeller, Simone Kurt, Henning Scheich, Holger Schulze,