کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4346932 1296811 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immobility in the tail suspension test predicts quinine but not saccharin intake in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Immobility in the tail suspension test predicts quinine but not saccharin intake in mice
چکیده انگلیسی

It is assumed that depressive symptomatology can alter taste preferences in humans. The aim of the present study was to search for correlations between immobility in the tail suspension test (TST) and consumption of saccharin (0.0025–0.1%, w/w) and quinine (0.0024–0.04%) solutions. Male C57BL/6J mice were divided into high immobility and low immobility groups based on their immobility scores in the TST. The groups consumed similar amounts of saccharin solutions in the two-bottle choice test. There were significant differences between the groups in quinine intake and preference. Intake of, and preference for, 0.0024% quinine was significantly higher in the high immobility than in low immobility subjects. In line with some animal and human studies, our results suggest that behavioral despair in the TST can correlate with taste responses to bitter stimuli.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 461, Issue 3, 15 September 2009, Pages 285–288
نویسندگان
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