کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4346976 1296814 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex
چکیده انگلیسی

In this study, we examined the changes in gene expression in the mouse cortex following chronic stress and behavioral tests. Mice were subjected to immobilization stress for 2 h per day for 15 consecutive days and the behavior of the mice was examined. The mice in the experimental group were more anxious and depressive than the control mice. The expression of mRNA in the cortex was analyzed by microarray analysis and 63 genes were found to show a greater than twofold change in expression between the control and experimental groups. Transthyretin was further investigated because its expression showed the greatest fold change. Transthyretin mRNA expression decreased in a chronic stress-specific manner, and protein levels were reduced in the cortex but not in the choroid plexus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 461, Issue 2, 11 September 2009, Pages 121–125
نویسندگان
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