کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347065 1296819 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Apolipoprotein E modulates auditory event-related potentials in healthy aging
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Apolipoprotein E modulates auditory event-related potentials in healthy aging
چکیده انگلیسی
42 individuals ranging from 47 to 73 years of age underwent an auditory three-stimulus oddball task while their event-related potentials (ERPs) were recorded. Half were APOE ɛ3 homozygotes and the remaining participants were either ɛ3/ɛ4 heterozygotes (n = 13), or ɛ4 homozygotes (n = 8). Analyses of variance showed that the heterozygotes had lower N1 amplitudes than the ɛ3 homozygotes, consistent with a previous study of participants with mild cognitive impairment (MCI) [I. Reinvang, T. Espeseth, L. Gjerstad, Cognitive ERPs are related to ApoE allelic variation in mildly cognitively impaired patients, Neuroscience Letters 382 (3) (2005) 346-351]. APOE genotype also significantly modulated N2 latency. ɛ4 homozygotes had longer N2 latencies, and importantly, longer N2 latencies predicted decline in verbal learning after 3.5 years follow up. These findings indicate a potential clinical significance of individual differences in ERP components N1 and N2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 459, Issue 2, 7 August 2009, Pages 91-95
نویسندگان
, , ,