کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347065 | 1296819 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Apolipoprotein E modulates auditory event-related potentials in healthy aging
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
42 individuals ranging from 47 to 73 years of age underwent an auditory three-stimulus oddball task while their event-related potentials (ERPs) were recorded. Half were APOE É3 homozygotes and the remaining participants were either É3/É4 heterozygotes (n = 13), or É4 homozygotes (n = 8). Analyses of variance showed that the heterozygotes had lower N1 amplitudes than the É3 homozygotes, consistent with a previous study of participants with mild cognitive impairment (MCI) [I. Reinvang, T. Espeseth, L. Gjerstad, Cognitive ERPs are related to ApoE allelic variation in mildly cognitively impaired patients, Neuroscience Letters 382 (3) (2005) 346-351]. APOE genotype also significantly modulated N2 latency. É4 homozygotes had longer N2 latencies, and importantly, longer N2 latencies predicted decline in verbal learning after 3.5 years follow up. These findings indicate a potential clinical significance of individual differences in ERP components N1 and N2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 459, Issue 2, 7 August 2009, Pages 91-95
Journal: Neuroscience Letters - Volume 459, Issue 2, 7 August 2009, Pages 91-95
نویسندگان
Thomas Espeseth, Helge Rootwelt, Ivar Reinvang,