کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347240 1296829 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for glutamatergic neurotransmission in cognitive control in an auditory attention task
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Evidence for glutamatergic neurotransmission in cognitive control in an auditory attention task
چکیده انگلیسی

There is little knowledge regarding the underlying mediating factors for cognitive control at the synaptic level, especially the role played by glutamatergic neurotransmission. In the current study the effect of the NMDA receptor antagonist memantine was examined in a pharmacological fMRI study. Thirty-one healthy adults were scanned twice in a counter-balanced design, either drug naïve or after administration of memantine for 21 days, to build up a steady-state plasma concentration in all participants. The participants performed an auditory attention control task while in the MR scanner. The results showed significant reduction in activation in prefrontal cortex and anterior cingulate cortex after memantine administration compared to the drug naïve session. We suggest that the present results may have implications for the understanding of deficits in cognitive control in psychiatric disorders, like schizophrenia, through altered glutamatergic neurotransmission.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 454, Issue 3, 1 May 2009, Pages 171–175
نویسندگان
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