کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347274 | 1296830 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The driving system for hippocampal theta in the brainstem: An examination by single neuron recording in urethane-anesthetized rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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![عکس صفحه اول مقاله: The driving system for hippocampal theta in the brainstem: An examination by single neuron recording in urethane-anesthetized rats The driving system for hippocampal theta in the brainstem: An examination by single neuron recording in urethane-anesthetized rats](/preview/png/4347274.png)
چکیده انگلیسی
The brainstem has been shown to be involved in generating hippocampal theta; however, which brainstem region plays the most important role in generating the rhythm has remained unclear. To reveal which brainstem region triggers the theta, the hippocampal local field potential was recorded simultaneously with single unit activity in the brainstem of urethane-anesthetized rat. The firing latencies before theta onset and offset were compared among recording sites (deep mesencephalic nucleus, DpMe; pedunculopontine tegmental nucleus, PPT; nucleus pontis oralis, PnO). We examined the activities of 59 cells; PPT showed the highest proportion of neurons changing their firing rates at theta onset (14/16, 87.5%). The proportion in the PnO was 14/22 (63.6%), but the neurons in the PnO showed the earliest changes in latencies (0.57Â s before theta onset). The change in the PPT was 0.96Â s after theta onset. Regarding the theta offset, the PPT showed the highest proportion of neurons changing their firing rates at theta offset (9/16, 56.3%; the proportion in the PnO was 5/22, 22.7%), but the difference in latent time was not significant among recorded regions. The neurons in the DpMe did not show any remarkable firing tendency at theta onset and offset. From these results, we propose a driving system of hippocampal theta, in which neurons in the PnO first trigger the theta onset and then those in the PPT maintain the theta by activating broadly the brainstem areas for the wave.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 455, Issue 1, 8 May 2009, Pages 65-69
Journal: Neuroscience Letters - Volume 455, Issue 1, 8 May 2009, Pages 65-69
نویسندگان
Yuji Takano, Yasuhiro Hanada,