کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347276 | 1296830 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-d-aspartate receptor antagonist in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-d-aspartate receptor antagonist in mice Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-d-aspartate receptor antagonist in mice](/preview/png/4347276.png)
چکیده انگلیسی
Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in regulating arousal and anxiety. NPS receptor (NPSR) mRNA is expressed significantly in the major input and output regions of hippocampal formation, which are critical in the modulation of learning and memory. However, the role of NPS/NPSR system in regulating of learning and memory is still unknown. Here, we use the Morris water maze (MWM) to determine the effects of NPS on spatial learning and memory following intracerebroventricular (i.c.v.) injection in mice. Our data show that i.c.v. injection of NPS facilitates spatial memory in the MWM without significant alteration of latency to the target and swimming speed. Furthermore, NPS (i.c.v.) mitigates spatial memory impairment induced by the selective N-methyl-d-aspartate receptor antagonist MK801. Taken together, our results firstly demonstrate that NPS facilitates spatial memory and mitigates MK801-induced spatial memory impairment in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 455, Issue 1, 8 May 2009, Pages 74-77
Journal: Neuroscience Letters - Volume 455, Issue 1, 8 May 2009, Pages 74-77
نویسندگان
Ren-Wen Han, Xin-Qiang Yin, Min Chang, Ya-Li Peng, Wei Li, Rui Wang,