کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347478 | 1296843 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effect of different regions of Nogo-A on the differentiation of neural progenitors Effect of different regions of Nogo-A on the differentiation of neural progenitors](/preview/png/4347478.png)
Nogo-A is an inhibitor of neurite outgrowth and axonal regeneration after CNS injury. Several functional regions including Nogo-66 were identified to mediate the inhibitory effect of Nogo-A. We have reported that Nogo-66 could promote neural progenitors to differentiate into glial cells. Here we exam three other regions of Nogo-A and show two of them also mediate the differentiation of neural progenitors. A 172-residues N-terminal region and a 37-residues C-terminal region of Nogo-A both could inhibit neuronal differentiation and promoted glial cell formation. This study illustrated that Nogo-A had multiple functional domains on the behavior of neuronal cells. The inhibitory effect of neural differentiation of Nogo-A may also contribute to its restraint of CNS repair.
Journal: Neuroscience Letters - Volume 458, Issue 3, 24 July 2009, Pages 132–135