کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347550 | 1296848 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In search of human oligodendroglia for myelin repair
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Cell therapy appears as an exciting strategy for myelin repair in pathologies where oligodendrocytes are deficient or impaired, such as leucodystrophies and multiple sclerosis. Many studies indicate that several types of rodent cells, including neural stem and progenitor cells, play a beneficial role after grafting and induce functional recovery in animal models of myelin disorders. However, the difficulties to commit human neural stem cells towards the oligodendroglial lineage have long hampered human cell-based therapy for these diseases. In this review, we present recent advances in the field and discuss the various strategies that helped overcome the challenge of human oligodendroglial differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 456, Issue 3, 12 June 2009, Pages 112–119
Journal: Neuroscience Letters - Volume 456, Issue 3, 12 June 2009, Pages 112–119
نویسندگان
Delphine Buchet, Anne Baron-Van Evercooren,