کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347717 | 1615179 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis](/preview/png/4347717.png)
چکیده انگلیسی
Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical severity of EAE, and a reduced infiltration of lymphocytes was observed based on a histological analysis. The expression of inducible NO synthase (iNOS) in the spinal cords appeared to be reduced by the treatment with edaravone and this effect was confirmed in vitro. A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 440, Issue 3, 8 August 2008, Pages 323–326
Journal: Neuroscience Letters - Volume 440, Issue 3, 8 August 2008, Pages 323–326
نویسندگان
Masayuki Moriya, Yuji Nakatsuji, Katsuichi Miyamoto, Tatsusada Okuno, Makoto Kinoshita, Atsushi Kumanogoh, Susumu Kusunoki, Saburo Sakoda,