کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347717 1615179 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis
چکیده انگلیسی

Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical severity of EAE, and a reduced infiltration of lymphocytes was observed based on a histological analysis. The expression of inducible NO synthase (iNOS) in the spinal cords appeared to be reduced by the treatment with edaravone and this effect was confirmed in vitro. A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 440, Issue 3, 8 August 2008, Pages 323–326
نویسندگان
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