کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347733 1296857 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of aminoguanidine in brain protection in surgical brain injury in rat
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Role of aminoguanidine in brain protection in surgical brain injury in rat
چکیده انگلیسی
The study investigated the effect of aminoguanidine (AG) on surgical brain injury (SBI) in rat. AG (75, 150 and 300 mg/kg, i.p.) was administered immediately following surgical resection. Using a SBI model, we found that AG (150 mg/kg) significantly reduced cerebral edema, while AG at the doses of 75 and 300 mg/kg had no effect. And AG (150 mg/kg) significantly reduced Evans Blue extravasation into brain tissue and improved the neurological outcome compared to control group. Moreover, the expression of TNF-α and nuclear factor-κB (NF-κB) mRNA and protein in brain tissue at the edge of the resection site increased at 24 h after SBI, which could be significantly attenuated by the treatment with AG via RT-PCR and Western blots methods. Our results demonstrated that SBI causes increased brain edema, BBB disruption and inflammation along the periphery of the site of surgical resection, which could be significantly improved by the treatment of AG.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 448, Issue 2, 26 December 2008, Pages 204-207
نویسندگان
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