کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347823 | 1296862 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stimulation of basolateral amygdaloid serotonin 5-HT2C receptors promotes the induction of long-term potentiation in the dentate gyrus of anesthetized rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
We have previously found that the induction of hippocampal long-term potentiation (LTP) is modulated by neuron activities in the basolateral amygdala (BLA). However, little is known about what neurotransmitter system in the BLA contributes to modulation of hippocampal LTP. In the present study, we investigated possible involvement of BLA serotonergic system in the induction of LTP at the perforant path (PP)-dentate gyrus (DG) granule cell synapses of anesthetized rats. The induction of PP-DG LTP was significantly inhibited by intra-BLA injection of the 5-HT2 receptor antagonist cinanserin (25-50Â nmol), but not by intra-BLA injection of the 5-HT1,7 receptor antagonist methiothepin (50Â nmol), the 5-HT3 receptor antagonist ondansetron (50Â nmol) or the 5-HT4 receptor antagonist RS23597-190 (100Â nmol). In addition, intra-BLA injection of the 5-HT2C receptor agonist MK212 (50Â nmol) facilitated the induction of PP-DG LTP. These results suggest that the induction of PP-DG LTP is promoted by activation of 5-HT2C receptors in the BLA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 451, Issue 1, 13 February 2009, Pages 65-68
Journal: Neuroscience Letters - Volume 451, Issue 1, 13 February 2009, Pages 65-68
نویسندگان
Kazuho Abe, Taiki Fujimoto, Tatsuhiro Akaishi, Miwa Misawa,