کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348160 1296879 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Herpes simplex virus type 1 induces filopodia in differentiated P19 neural cells to facilitate viral spread
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Herpes simplex virus type 1 induces filopodia in differentiated P19 neural cells to facilitate viral spread
چکیده انگلیسی

Herpes simplex virus type-1 (HSV-1) is a neurotropic virus with significant potential as a viral vector for central nervous system (CNS) gene therapy. This study provides visual evidence that recombinant green fluorescent protein (GFP)-expressing HSV-1 travel down dendrites in differentiated P19 neuronal-like cells to efficiently reach the soma. The virus also promotes cytoskeletal rearrangements which facilitate viral spread in vitro, including often dramatic increases in dendritic filopodia. Viral movements, cell infection and filopodia induction were each reduced with the actin polymerization inhibitor cytochalasin D, suggesting the involvement of the actin cortex in these processes. The observation of neural cytoskeletal reorganization in response to HSV-1 may shed light on the mechanisms by which acute viral infection associated with herpes encephalitis produces cognitive deficits in patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 440, Issue 2, 1 August 2008, Pages 113–118
نویسندگان
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