کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348170 1296879 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Postnatal oxytocin treatment of spontaneously hypertensive male rats decreases blood pressure and body weight in adulthood
چکیده انگلیسی

Postnatal oxytocin treatment decreases blood pressure and increases body weight in adult normotensive rats. The aim of the present study was to investigate the effect of postnatally administered oxytocin on blood pressure, heart rate and body weight in spontaneously hypertensive rats (SHR). For this purpose SHR male pups were given oxytocin (1 mg/kg) or saline subcutaneously once a day on days 10–14 after birth. Blood pressure and heart rate were measured at the age of 2 months. Weight was registered continuously. The postnatally oxytocin-treated male SHR had significantly lower systolic blood pressure as adults compared to the controls (158 vs. 169; p < 0.05). They also had a tendency to lower diastolic blood pressure (119 vs. 128; p = 0.10). Heart rate was equal in the two groups. The postnatally oxytocin-treated male SHR had a significantly lower body weight at the age of 5–8 weeks compared to the controls (ANOVA p = 0.014).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 440, Issue 2, 1 August 2008, Pages 166–169
نویسندگان
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