کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348236 1296882 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells
چکیده انگلیسی

Brain edema formation following brain injury is a serious but still poorly treatable medical condition. The understanding of volume regulation in astrocytes, the main cells involved in the formation of cytotoxic brain edema, is key for the development of novel treatment strategies. This study investigates the role of potassium-chloride cotransporters (KCC) for cell volume regulation in glial cells. PCR revealed the expression of KCC isoforms in a glial cell line (C6) and primary cultured astrocytes. Specific inhibition of KCCs caused glial cell swelling and resulted in a complete inhibition of regulatory volume decrease upon hypotonic medium-induced cell swelling. Therefore, our results show that KCCs play an important role in the maintenance and regulation of cell volume in astrocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 442, Issue 3, 19 September 2008, Pages 219–223
نویسندگان
, ,