کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4348266 | 1296883 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cocaine exposure during the early postnatal period diminishes medial frontal cortex Gs coupling to dopamine D1-like receptors in adult rat Cocaine exposure during the early postnatal period diminishes medial frontal cortex Gs coupling to dopamine D1-like receptors in adult rat](/preview/png/4348266.png)
The effect of cocaine exposure during early postnatal ages on coupling of dopamine (DA) D1- and D2-like receptors to their respective Gs/olf and Gi was examined in striatum and medial frontal cortex (MFC). Sprague–Dawley rats were subcutaneously injected with either 50 mg/kg cocaine or vehicle during postnatal day (PnD) 11–20 and dopaminergic D1- and D2-like receptor signaling was evaluated at PnD 60. Results showed that cocaine exposure did not affect the magnitude of both DA D1- and D2-like receptor coupling to their respective Gs/olf and Gi in striatum. However, in the medial frontal cortex, the basal and the DA D1-like receptor and Gs association were reduced in cocaine-exposed brains. However, there was no change in basal or DA D2-like receptor-Gi linkage in medial frontal cortex. Since frontal cortex plays a critical role in regulating cognition and working memory, disruption of DA-modulated circuits or alteration of dopaminergic activity resulting from postnatal cocaine exposure may result in abnormal responses to environmental challenges leading to long-term behavioral changes.
Journal: Neuroscience Letters - Volume 438, Issue 2, 20 June 2008, Pages 159–162