کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4348385 | 1296888 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CoCl2-induced expression of p300 promotes neuronal-like PC12 cell damage
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Hypoxia inducible factor-1 (HIF-1) is an important transcription activator involved in cell responses to hypoxic stress. Previous studies demonstrated that HIF-1 exerts both pro- and anti-survival effects under hypoxia. The mechanisms underlying these contrary effects of HIF-1 remain unclear. Transcription co-activator p300 is necessary for HIF-1-induced transcriptional activation. Many factors inhibit HIF-1 activity by competitively binding to p300, which suggests that p300 is a key player in the modulation of HIF-1 function. To examine the alteration of p300 expression under hypoxia and its role in hypoxia-induced neuronal damage, neuronal-like PC12 cells were cultured with cobalt chloride (CoCl2), a hypoxia mimic reagent. The results showed that CoCl2 treatment-induced p300 expression along with an increase in cell damage. Furthermore, CoCl2-induced cell damage was attenuated by suppression of p300 expression with short hairpin RNA (shRNA). The data suggests that CoCl2-induced up-regulation of p300 expression promotes neuronal-like PC12 cell damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 441, Issue 3, 29 August 2008, Pages 272-276
Journal: Neuroscience Letters - Volume 441, Issue 3, 29 August 2008, Pages 272-276
نویسندگان
Xiao Ling Tan, Xiao Yong Huang, Wen Xiang Gao, Yu Zai, Qing Yuan Huang, Yong Jun Luo, Yu Qi Gao,