کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348447 1296891 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR
چکیده انگلیسی

The atypical serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is believed to be essential to the regulation of cell growth and the functions of the central nervous system. By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultured hippocampal neurons, we found that rapamycin significantly reduces the spontaneous activities of network neurons as well as the efficacy of synaptic transmission through insulin-mTOR signaling pathway. Our study sheds light on understanding the role of mTOR signaling pathway in controlling the information processing of network neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 441, Issue 1, 15 August 2008, Pages 50–55
نویسندگان
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