کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348462 1296891 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats
چکیده انگلیسی

Recently, it has been known that the antinociception of sildenafil, a phosphodiesterase 5 inhibitor, is mediated through the opioid receptors. There are common three types of opioid receptors μ, δ, and κ. We characterized the role of subtypes of opioid receptor for the antinociception of sildenafil at the spinal level. Intrathecal catheters were placed for drug delivery and formalin solution (5%, 50 μl) was injected for induction of nociception within male SD rats. The effect of μ opioid receptor antagonist (CTOP), δ opioid receptor antagonist (naltrindole), and κ opioid receptor antagonist (GNTI) on the activity of sildenafil was examined. Intrathecal sildenafil decreased the flinching responses during phases 1 and 2 in the formalin test. Intrathecal CTOP and naltrindole reversed the antinociception of sildenafil during both phases in the formalin test. Intrathecal GNTI reversed the effect of sildenafil during phase 2, but not phase 1. These results suggest that sildenafil is effective to acute pain and the facilitated pain state at the spinal level. Both μ and δ opioid receptors are involved. However, it seems that κ opioid receptors play in the effect of sildenafil.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 441, Issue 1, 15 August 2008, Pages 125–128
نویسندگان
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