کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4348970 | 1615182 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low doses of apomorphine transiently reduce locomotor activity in MPTP-treated mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Parkinson's disease patients sometimes experience deterioration of motor function to below their baseline “off” state, termed the “super-off” state. We used low subthreshold (0.05Â mg/kg) to threshold (0.10 and 0.20Â mg/kg) doses of apomorphine to demonstrate the “super-off” state in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-lesioned mice. Twenty-four mice were randomized to receive apomorphine or vehicle. Within 20Â min of administration, 0.10 and 0.20Â mg/kg apomorphine-treated mice had less locomotion than controls. At the 100Â min time point, 0.10Â mg/kg apomorphine-treated mice had greater locomotion than controls. One week of suprathreshold levodopa pretreatment did not alter the response to these low apomorphine doses. Our results suggest that low doses of apomorphine can initially depress locomotion and subsequently stimulate locomotion, in a manner similar to what is seen in Parkinson's disease patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 428, Issues 2â3, 27 November 2007, Pages 64-67
Journal: Neuroscience Letters - Volume 428, Issues 2â3, 27 November 2007, Pages 64-67
نویسندگان
Steven A. Gunzler, Saate Shakil, Nichole E. Carlson, John G. Nutt, Charles K. Meshul,