کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349432 | 1296941 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Induction of the galanin-like peptide gene expression in the posterior pituitary gland after acute osmotic stimulus in rats Induction of the galanin-like peptide gene expression in the posterior pituitary gland after acute osmotic stimulus in rats](/preview/png/4349432.png)
Galanin-like peptide (GALP) is a 60 amino-acid peptide, and the GALP mRNA is restricted to pituicytes in the posterior pituitary gland (PP) and neurons in the hypothalamic arcuate nucleus (Arc). We examined whether the GALP gene expression in the PP and Arc would be induced after intraperitoneal (i.p.) administration of hypertonic saline, that is, acute osmotic stimulus, in rats. The dose–response (2.8, 4.5, 6.0 and 9.0% NaCl) and time-course (6.0% NaCl, 1, 3, 6, 12 and 24 h) effects of acute osmotic stimulus on GALP mRNA levels in the PP and Arc were examined in rats by using in situ hybridization histochemistry. Plasma osmolality and plasma sodium concentration increased significantly at 1 h, and returned to control level at 6 h after i.p. administration of hypertonic saline (6.0% NaCl). The GALP mRNA level in the PP increased significantly 3 and 6 h after i.p. administration of hypertonic saline (6.0% NaCl), but the level in the Arc did not change. These results showed that acute osmotic stimulus-induced GALP gene expression in the pituicyte of the PP, but not in the neurons in the Arc, and the gene expression in the pituicyte might be regulated by plasma osmolality and/or plasma sodium concentration.
Journal: Neuroscience Letters - Volume 419, Issue 2, 29 May 2007, Pages 125–130