کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4350312 1615187 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Candidate gene analysis of IP-10 gene in patients with Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Candidate gene analysis of IP-10 gene in patients with Alzheimer's disease
چکیده انگلیسی

Interferon-γ-inducible Protein-10 (IP-10) is supposed to play a role in Alzheimer's disease (AD) development, as demonstrated by increased levels in cerebrospinal fluid from patients with AD. A mutation scanning of IP-10 exonic region was carried out in 10 patients with AD and 10 age-matched controls, demonstrating the presence of two previously reported single nucleotide polymorphisms (SNPs) in exon 4 (G → C and T → C) as well as a novel SNP in exon 2 (C → T). Exon 4 G → C and T → C allelic variants were next evaluated in a population of 279 AD patients and 251 controls, in order to determine whether their presence could influence the susceptibility towards the development of the disease. These two SNPs were in complete linkage disequilibrium. No differences in haplotype frequencies were found in AD patients as compared with controls, even stratifying according to the presence of Apolipoprotein E ɛ4 allele, gender or age at onset. A new protocol was developed to easily determine the C → T SNP in exon 2. A preliminary analysis revealed a very low frequency of this allelic variant (1%). Therefore, the complete association study was not carried out because the size of our population was not sufficient to draw reliable conclusions. According to these results, IP-10 does not seem to be a risk factor for AD. However, a novel rare polymorphism has been identified, which could exert a role in AD susceptibility. Thus, further studies on larger populations are needed before confidently excluding IP-10 as a susceptibility gene for AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 404, Issues 1–2, 14 August 2006, Pages 217–221
نویسندگان
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