کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4350554 1615185 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2
چکیده انگلیسی

Many neuropeptides involved in pain perception are generated by endoproteolytic cleavages of their precursor proteins by the proprotein convertases PC1 and PC2. To investigate the role of PC2 in nociception and analgesia, we tested wild-type and PC2-null mice for their responses to mechanical and thermal nociceptive stimuli, before and after a short swim in cold or warm water. Basal responses and responses after a cold swim were similar between the two groups. However, after a short forced swim in warm water, PC2-null mice were significantly less responsive to the stimuli than wild-type mice, an indication of increased opioid-mediated stress-induced analgesia. The enhanced analgesia in PC2-null mice may be caused by an accumulation of opioid precursor processing intermediates with potent analgesic effects, or by loss of anti-opioid peptides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 406, Issues 1–2, 2 October 2006, Pages 71–75
نویسندگان
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