کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4350819 1615192 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute and chronic morphine alters formalin pain in neonatal rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Acute and chronic morphine alters formalin pain in neonatal rats
چکیده انگلیسی

The present study tested the hypothesis that morphine exposure during the human developmental equivalent of the third trimester would alter inflammatory pain. This study examined whether acute or continuous opioid exposure in the neonatal rat alters formalin-induced nociception after 4 days of abstinence. Rats were exposed to a single acute administration of morphine on postnatal day 7 or 72 h of opioid infusion from postnatal days 5–7 via osmotic pump. When challenged with intraplantar formalin on postnatal day 11, rats exposed to acute or chronic morphine had increased phase II pain-associated behaviors. These findings suggest that neonatal morphine exposure may have unintended consequences on inflammatory pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 400, Issues 1–2, 29 May 2006, Pages 154–157
نویسندگان
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