کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351084 | 1297006 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
COX-2 expression in the guinea pig cochlea is partly altered by moderate sound exposure
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The cyclooxygenase-2 isoform (COX-2) was found recently to be constitutively expressed in the guinea pig inner ear. To gain knowledge about its role in sound perception, alterations in the COX-2 level of moderate noise-stimulated cochleae were determined. Staining intensities were quantified in different regions using an immunohistochemical staining procedure and computer-assisted system. After 70Â dB and 90Â dB noise exposure for 1Â h at 8000Â Hz, COX-2 downregulation was observed in the organ of Corti, which was most prominent in Deiters' cells near Hensen cells and outer hair cells. In pillar cells, COX-2 levels were only slightly reduced after 70Â dB but strongly diminished after 90Â dB exposure. In Hensen cells, COX-2 was downregulated after 70Â dB stimulation, revealing a decreasing COX-2 content from the third to the first turn of the cochlea and a homogeneously reduced enzyme expression in all three turns after 90Â dB. The COX-2 content in inner hair cells was nearly identical to unexposed cochleae after 70Â dB exposure but significantly reduced after 90Â dB stimulation. In spiral ganglion cells, stria vascularis, spiral ligament and limbus, COX-2 expression was unchanged after 70Â dB and 90Â dB. We suggest that alterations in COX-2 expression might contribute to diminished sensitivity at the cochlea after noise exposure to reduce subsequent noise distress, termed sound conditioning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 394, Issue 2, 13 February 2006, Pages 121-126
Journal: Neuroscience Letters - Volume 394, Issue 2, 13 February 2006, Pages 121-126
نویسندگان
Ulf-Rüdiger Heinrich, Jürgen Brieger, Oxana Selivanova, Ralph Feltens, Antje Eimermacher, Dirk Schäfer, Wolf J. Mann,