کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4351095 | 1297007 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice](/preview/png/4351095.png)
This study investigated the cellular signaling pathways involved in the acute antidepressant-like action of memantine in the forced swimming test (FST) in mice. The immobility time in the FST was reduced by memantine (3–10 mg/kg, i.p.). The anti-immobility effect of memantine (3 mg/kg, i.p.) was prevented by pretreatment with H-89 (1 μg/site, i.c.v., an inhibitor of PKA), PD098059 (5 μg/site, i.c.v., an inhibitor of MAPK/ERK), KN-62 (1 μg/site, i.c.v., an inhibitor of CaMKII), but not with chelerythrine (1 μg/site, i.c.v., an inhibitor of PKC). Taken together, these results firstly demonstrate that the acute antidepressant-like effect of memantine seems to be dependent on the cellular signaling modulated by PKA, CaMKII and MAPK/ERK, but not by PKC.
Journal: Neuroscience Letters - Volume 395, Issue 2, 6 March 2006, Pages 93–97