کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351253 | 1297012 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct inflammatory stimuli
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct inflammatory stimuli Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct inflammatory stimuli](/preview/png/4351253.png)
چکیده انگلیسی
Increased lymphocyte trafficking across blood-brain barrier (BBB) is a prominent and early event in inflammatory and immune-mediated CNS diseases. The adhesion molecules that control the entry of leukocytes into the brain have not been fully elucidated. Although the role of ICAM-1 and VCAM-1 has been well documented, the expression and role of selectins is still a matter of controversy. In a mouse syngenic in vitro BBB model, highly relevant for examining immunological events, mouse brain capillary endothelial cells (MBCECs) do not express selectins. Treatment of MBCECs with LPS, induced E- and P-selectin expression, whereas TNF-alpha or IFN-gamma treatments did not. Finally, P-selectin but not E-selectin expression was induced in IL-1beta treated MBCECs. Thus, our study suggests that diverse inflammatory stimuli could differentially regulate selectin expression at the BBB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 392, Issue 3, 16 January 2006, Pages 216-220
Journal: Neuroscience Letters - Volume 392, Issue 3, 16 January 2006, Pages 216-220
نویسندگان
Caroline Coisne, Christelle Faveeuw, Yannick Delplace, Lucie Dehouck, Florence Miller, Roméo Cecchelli, Bénédicte Dehouck,