کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4351324 1615284 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Housing under abnormal light–dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Housing under abnormal light–dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice
چکیده انگلیسی


• Abnormal light–dark condition impaired the locomotor activity rhythm in mice.
• Abnormal light–dark condition causes the impairment of clock gene expression rhythm.
• Abnormal light–dark condition potentiates the immobility in forced-swimming test.
• Interaction between circadian impairment and depression is suggested.

Although the results of previous studies have suggested that disruptions in circadian rhythms are involved in the pathogenesis of depression, no studies have examined the interaction of clock gene expression deficit and depression state. In this study, we examined clock gene expression levels and depressive-like behavior in mice housed under 3.5 h light, 3.5 h dark (T = 7) conditions to investigate the association between clock gene expression and depressive state. C57BL/6J mice were housed under a T = 24 cycle (12 h light, 12 h dark) or a T = 7 cycle and clock gene expression levels in the hippocampus and the amygdala were measured by real-time RT-PCR. Depressive state was evaluated by the forced swim test (FST). Although circadian rhythms of Per1 and Per2 clock gene expression in the hippocampus and amygdala were still detected under T = 7 conditions, rhythmicity and expression levels of both significantly decreased. Mice housed with a T = 7 cycle showed increased immobile time in the FST than those with a T = 24 cycle. The present results suggest that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 and Per2 genes under abnormal light–dark conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 99, October 2015, Pages 16–21
نویسندگان
, , , , ,