کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351418 | 1615295 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish](/preview/png/4351418.png)
چکیده انگلیسی
The sex-determining region Y-box 2 (Sox2) is related not only to pluripotency, but also to cell proliferation. Zebrafish can regain their motor function after spinal cord injury (SCI). Following SCI, new motor neurons are produced from proliferating ependymal cells. Here, we investigated the expression and function of Sox2 after SCI in zebrafish. Sox2 was upregulated as early as 1 day post-lesion (dpl) in ependymal cells, which was followed by cell proliferation. Sox2 knockdown significantly decreased the number of proliferating cells at 5Â dpl. The results of this study suggest a role of Sox2 as one of the proliferation initiators in ependymal cells after SCI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 88, November 2014, Pages 84-87
Journal: Neuroscience Research - Volume 88, November 2014, Pages 84-87
نویسندگان
Kazuhiro Ogai, Kumi Nakatani, Suguru Hisano, Kayo Sugitani, Yoshiki Koriyama, Satoru Kato,