کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4351461 1615302 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve
چکیده انگلیسی
Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 80, March 2014, Pages 86-90
نویسندگان
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