Remodeling of hippocampal network in pilocarpine-treated mice expressing synaptopHluorin in the mossy fiber terminals

► SynaptopHluorin was used for direct investigation of mossy fiber sprouting. ► Its ectopic expression was evidenced after pilocarpine-induced seizures. ► Its abnormal expression was also enhanced in some layers of CA3a region. ► More widespread reorganization of network is suggested than previously expected.