Animal models of autism with a particular focus on the neural basis of changes in social behaviour: An update article

Research on autism has been gaining more and more attention. However, its aetiology is not entirely known and several factors are thought to contribute to the development of this neurodevelopmental disorder. These potential contributing factors range from genetic heritability to environmental effects. A significant number of reviews have already been published on different aspects of autism research as well as focusing on using animal models to help expand current knowledge around its aetiology. However, the diverse range of symptoms and possible causes of autism have resulted in as equally wide variety of animal models of autism.In this update article we focus only on the animal models with neurobehavioural characteristics of social deficit related to autism and present an overview of the animal models with alterations in brain regions, neurotransmitters, or hormones that are involved in a decrease in sociability.

► We summarized animal models of autism with changes in social behaviour.
► They are based on lesions in brain or changes (mutation) in genome.
► Behavioural deficit is associated with changes in brain.
► These changes include brain structures or neurotransmitter systems.