Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture

► Oroxylin A induced increase in intracellular calcium level and ERK MAPK phosphorylation. ► Oroxylin A phosphorylated cyclic AMP response element binding protein (CREB) followed with BDNF induction. ► These activities are mediated through GABAA receptor antagonism and NMDA receptor activation.