کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4351917 1298086 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The biological role of the glycinergic synapse in early zebrafish motility
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The biological role of the glycinergic synapse in early zebrafish motility
چکیده انگلیسی

Glycine mediates fast inhibitory neurotransmission in the spinal cord, brainstem and retina. Loss of synaptic glycinergic transmission in vertebrates leads to a severe locomotion defect characterized by an exaggerated startle response accompanied by transient muscle rigidity in response to sudden acoustic or tactile stimuli. Several molecular components of the glycinergic synapse have been characterized as an outcome of genetic and physiological analyses of synaptogenesis in mammals. Recently, the glycinergic synapse has been studied using a forward genetic approach in zebrafish. This review aims to discuss molecular components of the glycinergic synapse, such as glycine receptor subunits, gephyrin, gephyrin-binding proteins and glycine transporters, as well as recent studies relevant to the genetic analysis of the glycinergic synapse in zebrafish.


► We review molecular components of glycinergic synapse.
► Zebrafish is a good model animal to study glycinergic synapse.
► Glycine receptor and glycine transporter mutants have been studied in zebrafish.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 71, Issue 1, September 2011, Pages 1–11
نویسندگان
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