کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351928 | 1298086 | 2011 | 4 صفحه PDF | دانلود رایگان |

During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A1 and A2a antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30 mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window.
► Retinal lesions induce axonal sprouting of intact axons within superior colliculus.
► Caffeine treatment has opposite effects depending on the developmental time window.
► This drug may interfere with natural plasticity during brain development.
► Caffeine emerges as a facilitatory agent for neuronal plasticity in adulthood.
Journal: Neuroscience Research - Volume 71, Issue 1, September 2011, Pages 99–102