کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4353722 1298494 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parkinson's disease: Exit toxins, enter genetics
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Parkinson's disease: Exit toxins, enter genetics
چکیده انگلیسی

Parkinson's disease was long considered a non-hereditary disorder. Despite extensive research trying to find environmental risk factors for the disease, genetic variants now stand out as the major causative factor. Since a number of genes have been implicated in the pathogenesis it seems likely that several molecular pathways and downstream effectors can affect the trophic support and/or the survival of dopamine neurons, subsequently leading to Parkinson's disease. The present review describes how toxin-based animal models have been valuable tools in trying to find the underlying mechanisms of disease, and how identification of disease-linked genes in humans has led to the development of new transgenic rodent models. The review also describes the current status of the most common genetic susceptibility factors for Parkinson's disease identified up to today.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 90, Issue 2, 9 February 2010, Pages 146–156
نویسندگان
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