Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; LTF, Lactoferrin; KDa, kiloDalton; PD, Parkinson's disease; PIN, protein interaction network; GO, gene ontology; SNCA, Alpha-synuclein; PARK, protein Parkin; LRRK2, leucine-rich repeat kinase 2; PINK1, PTEN-induced putative kinase1; SNCAIP, Alpha-Synuclei
مقالات ISI LRRK2، کیناز 2 تکرار غنی از لوسین (ترجمه نشده)
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Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; LRRK2, leucine-rich repeat kinase 2; HTRA2, high temperature requirement protein A2; PD, Parkinson disease; PINK1, PTEN-induced putative kinase 1; IMS, intermembrane space; OMM, outer mitochondrial membr
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; αsyn, alpha-synuclein; CK, casein kinase; GFP, green fluorescent protein; LDH, lactate dehydrogenase; LRRK2, leucine-rich repeat kinase 2; MPP+, 1-Methyl-4-phenylpyridinium; n.s, not significant; PD, Parkinson's disease; PBS, phosphate-buffered saline; SN
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; DA, dopaminergic; ER, endoplasmic reticulum; 4E-BP1, eukaryotic initiation factor 4E (eIF4E)-binding protein; HD, Huntington's disease; LRRK2, leucine-rich repeat kinase 2; MPTP, 1-methyl-4-phen
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse model of Parkinson's disease
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; LRRK2, leucine-rich repeat kinase 2; PD, Parkinson's disease; RNS, reactive nitrogen species; ROS, reactive oxygen speciesNeurodegeneration; Parkinson's disease; Apocynin; Hyposmia
The identification of dysfunctional crosstalk of pathways in Parkinson disease
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; PD, Parkinson disease; DEGs, differentially expressed genes; LRRK2, leucine-rich repeat kinase 2; PINK1, PTEN-induced putative kinase 1; PARK, parkin; GBA, glucocerebrosidase; UCHL1, ubiquitin carboxyl-terminal esterase L1; SNCA, alpha-synuclein; GEO, Gen
Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; LRRK2, leucine-rich repeat kinase 2; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form); NOX2, NADPH oxidase isoform 2; NSAID, non-steroidal anti-inflammatory drug; PD, Parkinson's disease; PMA, phorbol-12-myristate-13-acetate; ROS, reactiv
Existing and emerging mitochondrial-targeting therapies for altering Parkinson's disease severity and progression
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; ATP, adenosine triphosphate; α-SYN [gene], alpha-synuclein; SNCA [protein], alpha-synuclein; Bcl-2, B-cell lymphoma 2; l-dopa, 3,4-dihydroxy-phenylalanine; DA, dopamine; LRRK2, leucine-rich repeat kinase 2; mtDNA, mitochondrial DNA; MAO-B, monoamine oxida
Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; Parkinson's disease; LRRK2; microglia; cytokine; neuroinflammationHBSS, Hank's balanced salt solution; IFN-γ, interferon gamma; LPS, lipopolysaccharide; LRRK2, leucine-rich repeat kinase 2; PD, Parkinson's disease; PBS, phosphate-buffered saline; TLR4, To
Aberrant striatal synaptic plasticity in monogenic parkinsonisms
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; Parkinson's disease; synaptic plasticity; striatum; animal modelDA, dopamine; DAT, DA transporter; LRRK2, leucine-rich repeat kinase 2; LTD, long-term depression; LTP, long-term potentiation; PD, Parkinson's disease; PET, positron emission tomography; SNC
Gene–environment interactions: Key to unraveling the mystery of Parkinson's disease
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; PD, Parkinson's disease; SN, substantia nigra; LPS, lipopolysaccharide; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NOS, nitric oxide synthase; LRRK2, Leucine-rich repeat kinase 2; PINK1, PTEN-induced putative kinase 1; GWAS, genome-wide associati
Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; LB, Lewy body; LRRK2, leucine-rich repeat kinase 2; MAPK, mitogen-activated protein kinase; MEK, MAPK/ERK kinase; PD, Parkinson's disease; SNCA, α-synucleinLRRK2; Mitogen-activated
Parkinson's disease: Exit toxins, enter genetics
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; ATP13A2, ATPase type 13A2; LRRK2, leucine-rich repeat kinase 2; PINK1, PTEN induced putative kinase 1; SNCA, synuclein alpha; TFAM, mitochondrial transcription factor A; UCH-L1, ubiquitin C-terminal esterase L1Genetic risk factors; PARK; Mutation; Animal
The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; Parkinson’s disease; Kinase; GTPase; AutophosphorylationCOR, C-terminal of ROC; LRRK2, leucine-rich repeat kinase 2; PD, Parkinson’s disease; ROC, ras of complex proteins
Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; Parkinson's disease; leucine-rich repeat kinase 2; elongation factor 1-alpha; GTPase; microtubules; dynamicsCor, C-terminal of Roc; EF1A, elongation factor 1-alpha; LRRK2, leucine-rich repeat kinase 2; MS, mass spectrometry; PBS, phosphate-buffered saline
Disease-modifying drugs and Parkinson's disease
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; AD, Alzheimer's disease; DA, dopamine; DAT, dopamine transporter; ER, endoplasmic reticulum; IGF-1, insulin-like growth factor 1; IMAO-B, inhibitors of monoamine oxidase B; LRRK2, leucine-rich repeat kinase 2; MAO-B, monoamine oxidase B; MPP+, 1-methyl-4-
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; Lrrk2; immunohistochemistry; Parkinson's disease; Lewy body; subventricular zone; neurogenesis; BAC; bacterial artificial chromosome; CRMP-2; collapsin response mediator protein-2; DAB; 3â²,3â² diaminobenzidine; DLBD; diffuse Lewy body disease; LRRK2;
The Parkinson’s disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activity
Keywords: LRRK2، کیناز 2 تکرار غنی از لوسین; PD, Parkinson’s disease; LRRK2, leucine-rich repeat kinase 2; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; GDI, guanine nucleotide dissociation inhibitor; GST, glutathione-S-transferase; IPTG, isopropyl β-d-thiogalactoside; SDS