کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278318 | 1295814 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
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کلمات کلیدی
PSA-NCAMCollapsin response mediator protein-2SVZCRMP-2DLBDLRRK2PBSTPBSDABBAC - LACLRRK2, leucine-rich repeat kinase 2 - LRRK2، کیناز 2 تکرار غنی از لوسینImmunohistochemistry - ایمونوهیستوشیمیLewy body - بدن لویdiffuse Lewy body disease - بیماری Lewy بدن پخش شده استParkinson’s disease - بیماری پارکینسونRoom temperature - دمای اتاقPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریsubventricular zone - منطقه فرعیNeurogenesis - نوروژنزbacterial artificial chromosome - کروموزوم مصنوعی باکتریایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease](/preview/png/6278318.png)
چکیده انگلیسی
Pathogenic substitutions in leucine-rich repeat kinase 2 (LRRK2, Lrrk2) have been genetically linked to familial, late-onset Parkinsonism. End-stage disease is predominantly associated with nigral neuronal loss and Lewy body pathology, but patients may have gliosis, tau or ubiquitin inclusions (pleomorphic pathology). The anatomical distribution of Lrrk2 protein may provide insight into its function in health and neurodegeneration, thus we performed a comparative study with 'in-house' and commercially available Lrrk2 antibodies using brain tissue from wild type and human Lrrk2 transgenic bacterial artificial chromosome (BAC) mice, and from diffuse Lewy body disease (DLBD) patients. Lrrk2 protein was ubiquitously expressed and relatively abundant in most brain regions, including the substantia nigra, thalamus and striatum. Lrrk2 was not a major component of Lewy body or neuritic pathology associated with Parkinson's disease. However, selective loss of dopaminergic neurons in Lrrk2-associated Parkinsonism argues the protein may have regional-specific interactions. Lrrk2 immunohistochemical staining was present in the subventricular zone, a region containing stem cells that give rise to both neurons and glia. A role for Lrrk2 in neurogenesis might provide further insight into the aberrant role of mutant protein in age-associated neurodegeneration with pleomorphic pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 147, Issue 4, 29 July 2007, Pages 1047-1058
Journal: Neuroscience - Volume 147, Issue 4, 29 July 2007, Pages 1047-1058
نویسندگان
H.L. Melrose, C.B. Kent, J.P. Taylor, J.C. Dachsel, K.M. Hinkle, S.J. Lincoln, S.S. Mok, J.G. Culvenor, C.L. Masters, G.M. Tyndall, D.I. Bass, Z. Ahmed, C.A. Andorfer, O.A. Ross, Z.K. Wszolek, A. Delldonne, D.W. Dickson, M.J. Farrer,