Keywords: MAPT; PARK2; GBA; PINK1; LRRK2;
مقالات ISI (ترجمه نشده)
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Keywords: Parkinson's disease; Genetics; LRRK2; GBA; Next-generation sequencing; North-Western Russian population;
Keywords: Parkinson's disease; Rodent models; Rodent behaviour; Animal models; Alpha-synuclein; LRRK2; GBA; 6-OHDA; Rotenone; MPTP; FBXO7; ATP13A2; VPS35; Parkin; PINK1; DJ-1;
Keywords: α-Syn; α-synuclein; AD; Alzheimer's disease; BP; Biological Process; CAMS; Chinese Academy of Medical Sciences; CAPS; calcium-dependent activator of secretion; CC; Cellular component; CCK; Cell counting kit; DA; dopamine; DAVID; Database for annotation,
Keywords: Parkinson's disease; Ghrelin; Dementia; AHN; adult hippocampal neurogenesis; AD; Alzheimer's Disease; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; AMP-activated protein kinase; AB; amyloid-β; ATG; autophagy-related; BBB; blood brain
Keywords: ADHD; Attention deficit hyperactivity disorder; APOE; Apolipoprotein E; cART; Combinatorial antiretroviral therapy; CEPH-HGDP; Centre d'Ãtude du polymorphisme humain-Human genome diversity panel; dbGaP; Database of genotypes and phenotypes; EGA; Europe
Keywords: Aβ; beta-amyloid; APOE; apolipoprotein E; APP; amyloid precursor protein; AD; Alzheimer's disease; CRISPR; clustered regularly interspaced short palindromic repeats; DAT; dopamine transporter; ER; estrogen receptor; FAD; familial Alzheimer's disease;
Keywords: LRRK2; Age; Glia; Neuroinflammation; Autophagy; Parkinson's disease; Adenoviral vector;
Keywords: PLK4; Polo-like kinase 4; FACS; fluorescence activated cell sorting; DMSO; dimethylsulfoxide; AML; acute myeloid leukemia; T-ALL; T-cell acute lymphoblastic leukemia; ABL1; Abelson Tyrosine-Protein Kinase 1; LRRK2; Leucine Rich Repeat Kinase 2; BRD4; Brom
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; amyloid-β; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; APOE4; apolipoprotein E4; APP; amyloid precursor protein; ASCL1; achaete-scute family basic helix-loop-helix transcription factor 1; ATP; adenosine trip
Keywords: BBB; blood-brain barrier; CSF; cerebral spinal fluid; COX1; cyclo-oxygenase 1; COX2; cyclo-oxygenase 2; CRP; C reactive protein; DA; dopamine; EGF; Epidermal growth factor; FACIT; functional assessment of chronic illness therapy; FcγRII; Fc gamma recepto
Keywords: Polyphenols; Antibiotics; Antioxidants; PACAP; Aβ; β-amyloid; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; CAT; catalase; CNS; central nervous system; COX-2; cyclooxyge
Keywords: sEH; soluble epoxide hydrolase; mEH; microsomal epoxide hydroxylases; EETs; Epoxyeicosatrienoic acids; PD; Parkinson's disease; SNCA; synuclein alpha; LRRK2; leucine-rich repeat kinase 2; PARK2; E3 ubiquitin-protein ligase parkin; PINK1; PTEN induced pu
Keywords: Alzheimer disease; Early-onset dementia; Tau; TDP-43; LRRK2; Exome sequencing;
Keywords: PD; Parkinson's disease; SNpc; substantia nigra pars compacta; LB; Lewy bodies; αSyn; αSynuclein; ER; endoplasmic reticulum; ERAD; ER-Associated Degradation; PINK1; PTEN-induced putative kinase 1; ATP13A2; lysosomal P-type transport ATPase; LRRK2; leuci
Keywords: AAO; age at onset; CIs; confidence intervals; GBA; glucocerebrosidase; LRRK2; leucine-rich repeat kinase 2; MAPT; microtubule-associated protein tau; NOS; Newcastle-Ottawa Scale; ORs; odds ratios; PD; Parkinson's disease; SNCA; a-Synuclein; meta-analy
Keywords: BD; Bipolar Disorder; STEP-BD; Systematic Treatment Enhancement Program for Bipolar disorder; DFNB31; Deafness, Autosomal Recessive 31; SORCS2; Sortilin-Related VPS10 Domain Containing Receptor 2; NRXN1; Neurexin 1; CNTNAP2; Contactin Associated Protein-L
Keywords: OS; oxidative stress; CNS; central nervous system; ROS; reactive oxygen species; SOD; superoxide dismutase; CAT; catalase; Cu; copper; Zn; zinc; Mn; manganese; Fe; iron; Ni; nickel; DA; dopamine; PHOX; NADPH oxidase; Nrf2; nuclear factor erythroid 2-relat
Keywords: Parkinson's disease; Cluster analysis; LRRK2; GBA; Genetic variants; Polymorphisms
Keywords: translation initiation factor; translation elongation factor; ribosome; EIF4G1; LRRK2; alpha-synuclein
Keywords: DAMP; danger-associated molecular pattern; GWAS; genome-wide association studies; IL; interleukin; iNOS; inducible nitric oxide synthase; iTreg; inflammatory suppressing inducible regulatory T cells; LPS; lipopolysaccharide; MHC; major histocompatibility;
Keywords: Dendritic spine; Synaptic plasticity; Neurodegenerative diseases; Psychiatric disorders; Glutamate receptor; Calcium signaling; ADHD; attention deficit hypersensitive disorders; FXS; Fragile X-syndrome; CNS; central nervous system; GABA; gamma amino butyr
Keywords: Catecholamine; Dopamine; Norepinephrine; Parkinson's disease; Neurodegeneration; AAG; autoimmune autonomic ganglionopathy; ALDH; aldehyde dehydrogenase; AMYL; amyloidosis; CAF; chronic autonomic failure; DA; dopamine; DHPG; 3,4-dihydroxyphenylglycol; DOPA
Keywords: Fluorescence-based biosensor; Kinase activity assay; LRRK2; Parkinson's disease; Inhibitor;
Keywords: Parkinson's disease; Autophagy; Macroautophagy; CMA; α-synuclein; LRRK2; VPS35; PINK1; Parkin; GBA; ATG13A2
Keywords: Parkinson's disease; Parkinsonism; Genetics; SNCA; LRRK2; VPS35; Parkin; PINK1; DJ-1; ATP13A2; PLA2G6; FBXO7; DNAJC6; SYNJ1
Keywords: Parkinson's disease; LRRK2; GBA; Genetic variant; Clinical profiles;
Keywords: Parkinson's disease; Inflammation; LRRK2; COX-2; RNA-binding proteins; NFκB;
Keywords: Antioxidant gene therapy; Brain ischemia; Neurodegenerative disorders; Oxidative stress; Virus-mediated gene delivery; ROS; ÎΨm; mitochondrial membrane potential; 3-NP; 3-nitropropionic acid; 6-OHDA; 6-hydroxydopamine; AADC; aromatic-l-amino decarboxyla
Keywords: Parkinson disease; Parkinsonism; Diffuse Lewy body disease; Transcranial sonography; PET; Glucocerebrosidase; GBA; Gaucher disease; LRRK2;
Keywords: SNc; substantia nigra pars compacta; PD; Parkinson disease; NMS; nonmotor symptoms; MAO-B; monoamine oxidase-B; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 6-OHDA; 6-hydroxy dopamine; GBA; glucocerebrosidase; STN
Keywords: AKAP1; A kinase anchoring protein 1; Endo B1; endophilin B1; ER; endoplasmic reticulum; GDAP1; ganglioside-induced differentiation-associated protein 1; GED; GTPase effector domain; GFP; green fluorescent protein; KO; knockout; LRRK2; leucine-rich repeat
Keywords: LB; Lewy body; PD; Parkinson's disease; SN; substantia nigra; ROS; reactive oxygen species; IRE/IRP; iron responsive element/iron responsive protein; NBIA; neurodegeneration with brain iron accumulation; KRS; Kufor-Rakeb syndrome; LRRK2; leucine rich re
CSF lamp2 concentrations are decreased in female Parkinson's disease patients with LRRK2 mutations
Keywords: Autophagy; Cerebrospinal fluid; Lamp2; LRRK2; Oxidative stress; Parkinson's disease;
Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey
Keywords: Parkinson's disease; ADPD; Turkey; LRRK2; SNCA;
Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response
Keywords: LRRK2; Zebrafish; Parkinson's disease;
Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors
Keywords: Pyrrolo[2,3-d]pyrimidine; LRRK2; Parkinson's disease; Kinase selectivity; CNS penetration;
Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology
Keywords: Parkinson's disease; LRRK2; Rab7L1; Phosphorylation; trans-Golgi;
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
Keywords: LRRK2; α-Synuclein; Tau; Tau phosphorylation; Lysosome; Parkinson's disease;
The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition
Keywords: Park8; Dardarin; Pharmacodynamics; Pharmacokinetics; Small-molecule inhibitor; LRRK2; Leucine-rich repeat kinase 2; PD; Parkinson disease; ATP; adenosine-tri phosphate; DTT; dithiothreitol; HSC70; Heat-shock cognate 70; Rab; Ras gene from rat brain, or Ra
Cognitive profile and 18F-fluorodeoxyglucose PET study in LRRK2-related Parkinson's disease
Keywords: Parkinson's disease; LRRK2; Cognitive; FDG-PET;
LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder
Keywords: REM sleep behavior disorder; Parkinson disease; Genetics; LRRK2;
Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy
Keywords: Manganese; Microglia; Neuroinflammation; LRRK2; Autophagy;
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology
Keywords: AMPK; 5â²AMP-activated protein kinase; LRRK2; Leucine rich repeat kinase; LAMP1; Lysosomal associated membrane protein 1; iPD; idiopathic PD; mTOR; mammalian target of rapamycin; LC3; microtubule-associated protein1A/1B light chain 3; PD; Parkinson's d
Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease
Keywords: Lrrk2; Parkinson's disease; Dopamine; Electrophysiology; Mouse model; eCB; endocannabinoids; G2019S; glycine to serine substitution at amino acid 2019; KD; kinase-dead; Lrrk2; leucine-rich repeat kinase2; Sulp; l-sulpiride; SPN; spiny projection neuron; P
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
Keywords: α-synuclein; G2019S knock-in mice; iba-1; LRRK2; Microglia; Parkinson's disease; AAV2/9; adeno-associated viral vector pseudotype 2/9; DA; dopamine; G2019S knock-in; G2019S KI; hα-syn; p.A53T human α-synuclein; ionized calcium binding adaptor molecule
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway
Keywords: LRRK2; Intracerebral hemorrhage; Secondary brain injury; p38 MAPK; Drosha; Neuronal apoptosis;
Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner
Keywords: 5-HT; 5-hydroxytryptamine; Aβ; β-amyloid; ABCA8; ATP binding cassette subfamily A member 8; AD; Alzheimer's disease; ADP; adenosine diphosphate; AGD; argyrophilic grain disease; ALS; amyotrophic lateral sclerosis; AMBRA-1; autophagy and beclin 1 regul
Fatigue correlates with LRRK2 G2385R variant in Chinese Parkinson's disease patients
Keywords: Parkinson's disease; Fatigue; LRRK2; G2385R variant;
Novel and functional ATG12 gene variants in sporadic Parkinson's disease
Keywords: PD; Parkinson's disease; ATG; autophagy-related gene; DSVs; DNA sequence variants; SNCA; alpha synuclein gene; LRRK2; leucine-rich repeat kinase 2; VPS35; vacuolar protein sorting 35; PINK1; PTEN-induced kinase 1; GBA; Glucocerebrosidase; CMA; chaperone-m