کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646338 | 1570093 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Towards diversity in genomics: The emergence of neurogenomics in Africa?
ترجمه فارسی عنوان
به سوی تنوع در ژنومیک: ظهور نوروژنومیک در آفریقا؟
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کلمات کلیدی
LRRK2Database of Genotypes and PhenotypesNeurogenomicsdbGaPHapmapEGACARTIEDBApoe - آپوapolipoprotein E - آپولیپوپروتئین Eattention deficit hyperactivity disorder - اختلال کمتوجّهی _ بیشفعالیAfrica - افریقاADHD - بیشفعالیPharmacogenomics - فارماکوژنومیکgenome wide association studies - مطالعات ارتباط گسترده ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومPrecision medicine - پزشکی دقیقsingle nucleotide polymorphism. - پلی مورفیسم تک نوکلئوتیدی.SNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
There is a high burden of mental and neurological disorders in Africa. Nevertheless, there appears to be an under-representation of African ancestry populations in large-scale genomic studies. Here, we evaluated the extent of under-representation of Africans in neurogenomic studies in the GWAS Catalog. We found 569 neurogenomic studies, of which 88.9% were exclusively focused on people with European ancestry and the remaining 11.1% having African ancestry cases included. In terms of population, only 1.2% of the total populations involved in these 569 GWAS studies were of African descent. Further, most of the individuals in the African ancestry category were identified to be African-Americans/Afro-Caribbeans, highlighting the huge under-representation of homogenous African populations in large-scale neurogenomic studies. Efforts geared at establishing strong collaborative ties with European/American researchers, maintaining freely accessible biobanks and establishing comprehensive African genome data repositories to track African genome variations are critical for propelling neurogenomics/precision medicine in Africa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 110, Issue 1, January 2018, Pages 1-9
Journal: Genomics - Volume 110, Issue 1, January 2018, Pages 1-9
نویسندگان
Emmanuel Quansah, Nathaniel W. McGregor,