Fatigue correlates with LRRK2 G2385R variant in Chinese Parkinson's disease patients
Keywords: Parkinson's disease; Fatigue; LRRK2; G2385R variant;
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CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons
Keywords: LRRK2-G2019S; CRISPR/Cas9; piggyBac; Parkinson's disease; hiPS; α-Synuclein; Serine129 phosphorylated α-Synuclein; PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; G2019S; Glycine 2019 mutated to Serine; SNpc; substantia nigra pars compacta
Functional properties of LRRK2 mutations in Taiwanese Parkinson disease
Keywords: ARHGEF7; GTPase; LRRK2; p.R1441H mutation; Parkinson disease;
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide
Keywords: Microglial priming; Aging; Parkinson's disease; MMP-8 inhibitor; Systemic inflammation; Neuroinflammation; CSF; macrophage colony-stimulating factor; EMSA; electrophoretic mobility shift assay; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium
Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice
Keywords: ChaRP; challenge-adjusted rod performance; ITI; inter-trial interval; LRRK2; leucine-rich repeat kinase 2; NAD; novel arm discrimination; ORP; overall rod performance; PD; Parkinson's disease; PSD-95; post synaptic density protein; RAWM; radial arm wate
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors
Keywords: 2-Aminopyridines; Parkinson's; Homology model; LRRK2; Kinativ;
Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods
Keywords: LRRK2; Virtual screening; Parkinson's disease; Homology modelling;
14-3-3 adaptor protein-protein interactions as therapeutic targets for CNS diseases
Keywords: 14-3-3; Axon; Parkinson's; LRRK2; Neurodegeneration; Fusicoccin; Drug;
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
Keywords: Genetic epidemiology; Parkinson's disease; LRRK2; PARK16;
MicroRNA-712 restrains macrophage pro-inflammatory responses by targeting LRRK2 leading to restoration of insulin stimulated glucose uptake by myoblasts
Keywords: miRNA/miR; microRNA; T2D; Type 2 diabetes; IP-10; interferon-γ-inducible protein 10; FFA; free fatty acids; BMDMs; bone marrow derived macrophages; ARG-1; arginase-1; YM-1; chitinase-1; LRRK2; leucine rich repeat kinase; 2-NBDG; 2-(N-(7-nitrobenz-2-oxa-1
Research articleAssociation between PARK16 and Parkinson's disease: A meta-analysis
Keywords: Parkinson's disease; PARK16; RAB7L1; Meta-analysis; LRRK2;
ReviewDysregulated microRNAs in neural system: Implication in pathogenesis and biomarker development in Parkinson's disease
Keywords: PD; Parkinson's disease; DA; dopaminergic; SN; substantia nigra; LRRK2; leucine repeat kinase 2; PINK1; PTEN-Induced Putative Kinase 1; ROS; reactive oxidative stress; AD; Alzheimer's disease; MPTP; methyl-4-phenyl-1,2,3,6-tetrahydropyridine; c/EBP-al
Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity
Keywords: LRRK2; Kinase; Cell death;
Serum lipid alterations in GBA-associated Parkinson's disease
Keywords: Parkinson's disease; Gaucher disease; GBA; LRRK2; sphingolipids; Biomarkers;
Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
Keywords: COR; C-terminal of Ras; CSF; cerebral spinal fluid; DAT-1; dopamine transporter-1; ERK5; extracellular-signal-regulated kinase 5; ExAC; Exome Aggregation Consortium; GTPase; Guanosine Triphosphate Hydrolase; LoF; loss of function; LRRK2; leucine-rich repe
LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death
Keywords: LRRK2; ASK1; MAPK; Neuronal cell death; Phosphorylation;
Research articleAutosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil
Keywords: Parkinson's disease; Autosomal dominant Parkinson's disease; LRRK2; SNCA; VPS35; GBA;
Comparative blood transcriptome analysis in idiopathic and LRRK2 G2019S-associated Parkinson's disease
Keywords: Parkinson's disease; LRRK2; Gene expression; RNA-seq; Trancriptome; Peripheral blood;
LRRK2 variation and dementia with Lewy bodies
Keywords: Dementia with Lewy bodies; Genetics; LRRK2; Parkinson's disease;
Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus
Keywords: Parkinson's disease; TaqMan; miR-144; miR-199b; miR-221; miR-488; miR-544; SNCA; PARK2; LRRK2;
Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors
Keywords: LRRK2; Parkinson's disease; Leucine rich repeat kinase; CNS; Kinase;
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity
Keywords: Parkinson's Disease; LRRK2; Dopamine; Stereology; MPTP; Genetic factor; Environmental factor;
Clinical heterogeneity of LRRK2 p.I2012T mutation
Keywords: Parkinson disease; LRRK2; I2012T; Frontotemporal dementia; Next generation sequencing;
Analysis of mitochondrial structure and function in the Drosophila larval musculature
Keywords: ATP; adenosine triphosphate; AEL; after egg laying; CMT2A; Charcot-Marie-Tooth Type 2A; ConA; concanavalin A; Drp1; dynamin-related protein; DOA; dominant optic atrophy; GFP; green fluorescent protein; IFM; indirect flight muscle; IMF; intermyofibrill
Bcl-xL-mediated antioxidant function abrogates the disruption of mitochondrial dynamics induced by LRRK2 inhibition
Keywords: Parkinson; LRRK2; DRP-1; Mitocondrial fission; Acetylated tubulin; Oxidative stress
Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
Keywords: Apoptosis; Autophagy; Endoplasmic reticulum; IP3 receptor; Lysosomes; Mitochondria; AMBRA1; autophagy/Beclin 1 regulator 1; AMPK; AMP-activated kinase; ATF4; activating transcription factor-4; Atg; autophagy-related; BIRD-2; Bcl-2/IP3R disruptor-2; CREB;
Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease
Keywords: mtDNA; mitochondrial DNA; ddPCR; digital droplet PCR; NMNC; non-manifesting non-carriers (subjects who do not carry the LRRK2G2019S mutation and do not manifest Parkinson's disease); NMC; non-manifesting carriers (subjects who carry the LRRK2G2019S mutati
Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases
Keywords: ÎΨm; membrane potential; AD; Alzheimer's disease; AMPK; adenosine-monophosphate-activated kinase; ATG proteins; autophagy-related proteins; ATP; adenosine triphosphate; CaMKs; calcium-calmodulin-activated kinases; CDKs; cyclin-dependent kinases; CNS;
Interaction between SNCA, LRRK2 and GAK increases susceptibility to Parkinson's disease in a Chinese population
Keywords: Parkinson's disease; SNCA; LRRK2; GAK; MDR; Gene–gene interaction
Identification of novel variants in LRRK2 gene in patients with Parkinson's disease in Serbian population
Keywords: Parkinson's disease; Genetics; LRRK2; PARK8; Late onset; Mutation;
The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews
Keywords: Parkinson's disease; SMPD1; GBA; LRRK2; Niemann-Pick disease; Gaucher disease;
Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls
Keywords: Parkinson's disease; Gene expression; RNA-seq; Transcriptome; LRRK2; Peripheral blood;
LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population
Keywords: LRRK2; A419V; rs34594498; Parkinson's disease; Cognitive impairment;
LRRK2 mutations in Parkinson disease; a sex effect or lack thereof? A meta-analysis
Keywords: Parkinson's disease; LRRK2; Genetics; Gender;
Neuropsychological performance in LRRK2 G2019S carriers with Parkinson's disease
Keywords: Parkinson; Genetics; LRRK2; Neuropsychological tests
Neural stem cell culture model for LRRK2 function determines regulation of dopaminergic and microtubule-associated genes
Keywords: Lrrk2; Neural stem cells; Cell culture model; Parkinson's disease;
Cognitive and behavioral symptoms in Parkinson's disease patients with the G2019S and R1441G mutations of the LRRK2 gene
Keywords: Parkinson's disease; Familial; Cognitive impairment; Neuropsychiatry; LRRK2; R1441G mutation
Clinical and imaging markers in premotor LRRK2 G2019S mutation carriers
Keywords: Parkinson; LRRK2; Genetic; Transcranial ultrasound; Substantia nigra;
Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking
Keywords: In silico; Joint pharmacophore space; Ensemble docking; LRRK2; Inhibitor;
Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release
Keywords: Parkinson's disease; LRRK2; Genetic models; Behavior; Cognition; Synaptosomes;
Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels
Keywords: Acidic Ca2+ stores; Evolution; Lysosomes; Lysosome-related organelles; Secretory vesicles; Vacuoles; Acidocalcisomes; TRP; Mucolipin; TPC; P2X4; IP3 receptor; Ryanodine receptor; NAADP; Membrane traffic; Secretion; LRRK2;
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease
Keywords: LRRK2; Kinase; Parkinsonism; Parkinson's disease; Adenovirus; Neurodegeneration; PARK8; Nigrostriatal
Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers
Keywords: ANOVA; analysis of variance; BSA; bovine serum albumin; ERM; ezrin/radixin/moesin; FSC; forward scatter; HBSS; Hanks balanced salt solution; LatA; Latrunculin A; LRRK2; leucine-rich repeat kinase 2; PBS; phosphate-buffered saline; PD; Parkinson's diseas
Neurodegenerative CSF markers in genetic and sporadic PD: Classification and prediction in a longitudinal study
Keywords: Parkinson; CSF; Tau; Abeta; LRRK2; GBA;
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease
Keywords: αSyn; alpha-synuclein; ALP; autophagy/lysosomal degradation pathway; CSF; cerebral spinal fluid; ERK5; extracellular-signal-regulated kinase 5; IL; interleukin; KI; knock-in; KO; knockout; LPS; lipopolysaccharide; LRRK2; leucine rich repeat kinase 2; MHC
MAPT IVS1+124 C>G modifies risk of LRRK2 G2385R for Parkinson's disease in Chinese individuals
Keywords: Parkinson's disease; Genetic association; MAPT; LRRK2; Interaction;
Confirmation of the association between LRRK2 R1628P variant and susceptibility to Parkinson's disease in the Thai population
Keywords: LRRK2; R1628P; Parkinson's disease; Early-onset Parkinson's disease;
LRRK2 mutations in Parkinson's disease: Confirmation of a gender effect in the Italian population
Keywords: Parkinson disease; Genetics; LRRK2; Gender;
Cognitive dysfunction in Parkinson's disease related to the R1441G mutation in LRRK2
Keywords: Cognitive impairment; Mood; Parkinson's disease; R1441G mutation; LRRK2;
No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals
Keywords: LRRK2; Variants; Alzheimer's disease; Han Chinese;