No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese
Keywords: Mitochondria; LRRK2; SNP; Schizophrenia; Replication; Han Chinese;
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Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients
Keywords: Parkinson's disease; DNA methylation; SNCA; LRRK2;
Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration
Keywords: LRRK2; leucine rich repeat kinase 2; LRRK2-3HA; C-terminal 3Ã-hemagglutinin tagged LRRK2; cDNA; complementary deoxyribonucleic acid; mEPSC; miniature excitatory postsynaptic current; PD; Parkinson's disease; AMPA; (2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-
ERKed by LRRK2: A cell biological perspective on hereditary and sporadic Parkinson's disease
Keywords: Parkinson disease; LRRK2; Autophagy; Cytoskeleton; MAPK; Mitophagy
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold
Keywords: AD; Alzheimer's disease; ANK; ankyrin repeat domain; ARM; armadillo repeat domain; AUC; area under the curve; BA; brain availability; BBB; blood brain barrier; BCRP; breast cancer related protein; BI; brain impairment; CSD; Cambridge Structural Database
The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
Keywords: Parkinson's disease; LRRK2; SNCA; MAPT; Interaction; Genetics;
LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis
Keywords: LRRK2; Parkinson's disease; Intracellular traffic; Quality control mechanisms; Mitochondria;
Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease
Keywords: LRRK2; Parkinson's disease; Kinase; GTPase; Inhibitor; Endocytosis; Autophagy; Vesicle trafficking; Neuronal dysfunction; Rab protein; AKAP; A-kinase anchoring protein; ANK; ankyrin repeat; AP; adaptor protein; ARM; armadillo repeat; CHIP; carboxyl termin
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging
Keywords: BAC; bacterial artificial chromosome; DA; dopamine; KI; knock-in; KD; kinase dead; LRRK2; leucine-rich repeat kinase 2; PD; Parkinson's disease; ROC; Ras Of Complex; WT; wild-type; Aging; D1994S knock-in; G2019S knock-in; H-1152; LRRK2 kinase-dead; LRRK2;
Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease
Keywords: SNCA140; PARK; RIN; Mixed-effects-model; miR-133b; NURR1; PITX3; UV-LMD; UCHL-1; ATPase13A2; Parkin; LRRK2;
Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration
Keywords: Parkinson's disease; LRRK2; PARK8; Dopaminergic; Nuclear envelope; Transgenic; Neurodegeneration;
Zebrafish as a model system for mitochondrial biology and diseases
Keywords: 2,5-DHBA; 2,5-dihydroxybenzoic acid; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; CMT2; Charcot-Marie-Tooth 2; CNS; central nervous system; coA; coenzyme A; COX; cytochrome c oxidase; DA; dopaminergic; dpf; da
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Keywords: Parkinson's disease; LRRK2; Mitochondrial DNA damage; Stem cells;
Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease
Keywords: Parkinson's disease; LRRK2; p.R1441G; Asia; Intrafamilial clinical heterogeneity;
Novel cinnoline-based inhibitors of LRRK2 kinase activity
Keywords: LRRK2; Leucine rich repeat kinase 2; Parkinson's disease; Kinase inhibitors;
Comprehensive LRRK2 and GBA screening in Portuguese patients with Parkinson's disease: Identification of a new family with the LRRK2 p.Arg1441His mutation and novel missense variants
Keywords: Parkinson's disease; Genetics; LRRK2; GBA; R1441H; Portugal;
The LRRK2 G2019S mutation status does not affect the outcome of subthalamic stimulation in patients with Parkinson's disease
Keywords: Parkinsons disease; STN-DBS; LRRK2;
Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: A replication study in a Taiwanese cohort
Keywords: Genetic susceptibility; SNCA; LRRK2; Replication study; Parkinson's disease;
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation
Keywords: LRRK2; leucine rich repeat kinase 2; ROC; ras of complex proteins; COR; C-terminal of ROC; PD; Parkinson's disease; ICC; Immunocytochemistry; LRRK2; Parkinson's disease; Autophagy; Lysosomes; Signaling pathways;
TDP-43 pathology in a patient carrying G2019S LRRK2Â mutation and a novel p.Q124E MAPT
Keywords: LRRK2; MAPT; Parkinson's disease; TDP-43; tau;
Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2
Keywords: Leucine-rich repeat kinase 2; LRRK2; LRRK2 inhibitors; Kinase inhibitors; Parkinson's disease;
The development of CNS-active LRRK2 inhibitors using property-directed optimisation
Keywords: PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; DLP1; dynamin-like protein 1; FOXO1; forkhead box transcription factor; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; SBDD; structure-based drug design; HTS; high throughput
ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
Keywords: IP; immunoprecipitates; LRRK2; leucine-rich repeat kinase 2; PD; Parkinson's disease; Roc; Ras of complex protein; SILAC; stable isotope labeling of amino acids in culture; LRRK2; Kinase domain; Activation segment; Conformation; Antibody; Immunoprecipitat
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases
Keywords: LRRK2; G2019S; α-Synuclein; Differential solubility; Immunohistochemistry;
Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity
Keywords: LRRK2; leucine-rich repeat kinase 2; DAT; dopamine transporter; DA; dopamine; Mn; manganese; HEK; human embryonic kidney; ROS; reactive oxygen species; JNK; c-Jun N-terminal kinases; p38; 38 mitogen-activated protein kinase; AP13A2; probable cation-transp
Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones
Keywords: ERK5 inhibitor; Kinase selectivity; Benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-one; BMK1; big MAP kinase 1; DIEA; N,N-diisopropylethylamine; DCAMKL2; doublecortin and CaM kinase-like 2; DMA; N,N-dimethylacetamide; EGF; epidermal growth factor; ERK5; extrace
Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation
Keywords: LRRK2; leucine-rich repeat kinase 2; PD; Parkinson's disease; S910/935; serine 910/935; HEK293; human embryonic kidney 293; FCS; fetal calf serum; PBMC; peripheral blood mononuclear cell; HRP; horseradish-peroxidase; LC-MS/MS; liquid chromatography mass
Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers
Keywords: Parkinson's disease; LRRK2; Executive functions; Stroop task;
Inhibition of LRRK2 kinase activity stimulates macroautophagy
Keywords: LRRK2; Leucine Rich Repeat Kinase 2; mTOR; Mammalian target of rapamycin; ROC; Ras of Complex Proteins; COR; C-terminal of ROC domain; SDS; Sodium dodecyl sulphate; EDTA; Ethylene di-ammonium tetra acetic acid; DPBS; Dulbecco's phosphate buffered saline;
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4
Keywords: F-actin; filamentous actin; G-actin; globular actin; LIMK; LIM domain kinase; LRRK2; leucine-rich repeat kinase 2; PAK; p21 protein (Cdc42/Rac)-activated kinase; qRT-PCR; quantitative reverse transcription polymerase chain reaction; GEF; guanine nucleotid
Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation
Keywords: Parkinson's disease; LRRK2; Heterodimer; Dominant-negative effect; Akt1 phosphorylation; Apoptosis;
The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease
Keywords: Mitochondrial dynamics; Bioenergetics; Parkinson's disease; Parkin; PINK1; LRRK2; Alpha-synuclein; DJ-1; Mitophagy; Fission; Fusion; Neurodegeneration; Neuron
Autosomal dominant Parkinson's disease
Keywords: Parkinson's disease; autosomal dominant genes; genetics of parkinsonism; LRRK2; SNCA; EIF4G; VPS35
Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease
Keywords: Parkinson's disease; Zambia; Genetics; SNCA; LRRK2; Parkin; PINK1; DJ-1;
GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
Keywords: LRRK2; Drug discovery; Kinase inhibitors; Parkinson's disease;
LRRK2 I2020T mutation is associated with tau pathology
Keywords: LRRK2; I2020T mutation; Pathology; Tau; PARK8
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease
Keywords: LRRK2; SCNA; UCHL1; HtrA2; GIGYF2; Autosomal dorminant Parkinson's disease
Research ReportBrain transcriptomic profiling in idiopathic and LRRK2-associated Parkinson's disease
Keywords: IPD; Idiopathic Parkinson's Disease; LC; locus coeruleus; Microarray; Parkinson's disease; LRRK2; Locus coeruleus;
Characterization of TAE684 as a potent LRRK2 kinase inhibitor
Keywords: JCKJRUBYLDAWAS-UHFFFAOYSA-N; BEFCJJXEVQNHEX-UHFFFAOYSA-N; FUEPMFVKEWEKFP-UHFFFAOYSA-N; Parkinson's disease; LRRK2; TAE684;
MicroRNAs in Parkinson's disease
Keywords: Parkinson; MicroRNA; α-synuclein; Neurodegeneration; Genetic; Gene regulation; mRNA translation; Dopamine; Neuron; LRRK2; Polymorphism;
Reduced LRRK2-positive neurons in the striatum of Parkinson's disease patients hypothesize a retrograde disease mechanism?
Keywords: LRRK2; Parkinson's disease; Immunohistochemistry; PARK8; Neurodegeneration;
Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants
Keywords: Parkinson’s disease; Penetrance; LRRK2; Genetic variants; Association
Microarray expression analysis in idiopathic and LRRK2-associated Parkinson's disease
Keywords: IPD; Idiopathic Parkinson's disease; MPD; LRRK2 G2019S mutation-associated Parkinson's disease; LTP; long-term potentiation pathway; Parkinson's Disease; LRRK2; Putamen; Gene expression; Microarray; Quantitative real-time PCR; Synaptic transmission; Synap
First neuropathological description of a patient with Parkinson’s disease and LRRK2 p.N1437H mutation
Keywords: Autosomal dominant parkinsonism; LRRK2; Alpha-synuclein; Ubiquitin; Deep brain stimulation; Suicide
LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin
Keywords: PD; Parkinson disease; LRRK2; leucine-rich repeat kinase 2; ROC; Ras of complex proteins; TH; tyrosine hydroxylase; PAL; protocerebral antero lateral; PAM; paired anterolateral medial; PPM; protocerebral posterior medial; DA; dopamine; IP; immunoprecipita
Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
Keywords: Parkinson's disease; LRRK2; microglia; cytokine; neuroinflammationHBSS, Hank's balanced salt solution; IFN-γ, interferon gamma; LPS, lipopolysaccharide; LRRK2, leucine-rich repeat kinase 2; PD, Parkinson's disease; PBS, phosphate-buffered saline; TLR4, To
Mitochondrial Ca2+ signals in autophagy
Keywords: mTOR; mammalian target of rapamycin; InsP3R; inositol 1,4,5-trisphosphate receptor; AMPK; adenosine monophosphate activated protein kinase; mTORC1; mammalian target of rapamycin complex 1; GAP; GTPase activating protein; TSC1/TSC2; tuberous sclerosis comp
Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson’s disease: A meta-analysis
Keywords: Parkinson’s disease (PD); LRRK2; PARK8; Variant; Meta-analysis
The Parkinson's disease-related genes act in mitochondrial homeostasis
Keywords: Mitochondrial homeostasis; Parkinson's disease; Alpha-synuclein; Parkin; DJ-1; PINK1; LRRK2;
LRRK2 expression is enriched in the striosomal compartment of mouse striatum
Keywords: LRRK2; Expression; Striosome; Knockout; Transgenic;