کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10596111 | 981897 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel cinnoline-based inhibitors of LRRK2 kinase activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel cinnoline-based inhibitors of LRRK2 kinase activity Novel cinnoline-based inhibitors of LRRK2 kinase activity](/preview/png/10596111.png)
چکیده انگلیسی
Leucine rich repeat kinase 2 (LRRK2) has been implicated in the pathogenesis of Parkinson's disease (PD). Inhibition of LRRK2 kinase activity is a therapeutic approach that may lead to new treatments for PD. Herein we report the discovery of a series of cinnoline-3-carboxamides that are potent against both wild-type and mutant LRRK2 kinase activity in biochemical assays. These compounds are also shown to be potent inhibitors in a cellular assay and to have good to excellent CNS penetration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 1, 1 January 2013, Pages 71-74
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 1, 1 January 2013, Pages 71-74
نویسندگان
Albert W. Garofalo, Marc Adler, Danielle L. Aubele, Simeon Bowers, Maurizio Franzini, Erich Goldbach, Colin Lorentzen, R. Jeffrey Neitz, Gary D. Probst, Kevin P. Quinn, Pam Santiago, Hing L. Sham, Danny Tam, Anh P. Truong, Xiaocong M. Ye, Zhao Ren,