Keywords: مهار کننده های کیناز; Dengue virus; Antivirals; Kinase inhibitors; Drug repurposing; Virus-host interactions;
مقالات ISI مهار کننده های کیناز (ترجمه نشده)
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Keywords: مهار کننده های کیناز; Kinase inhibitors; immune disorders; phosphoinositide 3-kinase; IPI-549;
Keywords: مهار کننده های کیناز; 5-FU; 5-fluorouracil; AF; atrial fibrillation; ALK; anaplastic lymphoma kinase; APD; action potential duration; APL; acute promyelocytic leukemia; BCR-ABL; breakpoint cluster region-Abelson; BTK; Bruton tyrosine kinase; CD20; cluster of differentiation 20
Keywords: مهار کننده های کیناز; ALK; anaplastic lymphoma kinase; ATP; adenosine triphosphate; BCR-ABL; Breakpoint cluster region-Abelson; DMEM; Dulbecco Modified Eagle Medium; EGFR; epidermal growth factor receptor; FUCCI; Fluorescence Ubiquitination Cell Cycle Indicator; HER; human e
Keywords: مهار کننده های کیناز; Phosphoproteomics; Kinase inhibitors; Drug resistance; Pazopanib; Dasatinib; Cell signalling;
Keywords: مهار کننده های کیناز; Kinase inhibitors; Selectivity; Ring closure; Rigidification; Abl; BRAF;
Keywords: مهار کننده های کیناز; BRAF; NRAS; MEK; Kinase inhibitors; Targeted therapy; Melanoma;
Keywords: مهار کننده های کیناز; Melanoma; Therapy; Kinase inhibitors; Immune checkpoint blockers; Survival;
Keywords: مهار کننده های کیناز; Chronic lymphocytic leukemia; Choice of therapy; Chemoimmunotherapy; Kinase inhibitors;
Keywords: مهار کننده های کیناز; 2-Imidazoline; Chemical instability; Microwave irradiation; Buchwald-Hartwig amination; Kinase inhibitors; Hinge region binders;
Keywords: مهار کننده های کیناز; Thyroid cancer; Cancer therapy; Protein kinases; Kinase inhibitors; Anti-angiogenetic therapy
Keywords: مهار کننده های کیناز; Discoidin domain receptors; Lung cancer; Signal transduction; Collagen; Kinase inhibitors;
Keywords: مهار کننده های کیناز; Peptidomimetics; Biotransformations; Cytostatic/cytotoxic effect; Kinase inhibitors;
Keywords: مهار کننده های کیناز; Kinase inhibitors; Rheumatoid arthritis;
Keywords: مهار کننده های کیناز; Fragment library; CK2; Kinase inhibitors; Fragment-based drug discovery
Place des inhibiteurs de JAK dans le traitement de la polyarthrite rhumatoïde
Keywords: مهار کننده های کیناز; Polyarthrite rhumatoïde; Anti-JAK; Petites molécules; Traitement; Inhibiteur de kinases; Rheumatoid arthritis; JAK inhibitors; Small molecules; Treatment; Kinase inhibitors;
The Akt-like kinase of Leishmania panamensis: As a new molecular target for drug discovery
Keywords: مهار کننده های کیناز; L. panamensis; Akt protein; Docking; Kinase inhibitors; Apoptosis;
Clinical Practice Guidelines for Diagnosis and Treatment of Chronic Lymphocytic Leukemia (CLL) in The Netherlands
Keywords: مهار کننده های کیناز; Chemo-immunotherapy; Health economics; Kinase inhibitors; Reimbursement; Small lymphocytic lymphoma;
Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts
Keywords: مهار کننده های کیناز; Polypharmacology; Kinase inhibitors; Malignancies; Drug resistance; Anti-cancer therapeutics;
CAR-T cells and combination therapies: What's next in the immunotherapy revolution?
Keywords: مهار کننده های کیناز; CAR; chimeric antigen receptor; iRs; inhibitory receptors; mAbs; monoclonal antibodies; SMIs; Small molecule inhibitors; KIs; kinase inhibitors; CAR-T cells; Solid tumors; Targeted-therapies; Combination therapies; Synthetic biology; Systems biology;
Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
Keywords: مهار کننده های کیناز; Hepaotocytes; Hepatotoxicity; Cytotoxicity; Kinase inhibitors;
New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors
Keywords: مهار کننده های کیناز; Benzothiopyranopyrimidines; KDR kinase; Antiproliferative activity; Kinase inhibitors; A-431; epidermoid carcinoma cell line; DMEDA; N,Nâ²-dimethylethylendiamine; HeLa; cervix adenocarcinoma cell line; h; human; HUVEC; human umbilical vein endothelial ce
Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε
Keywords: مهار کننده های کیناز; ATP; adenosine triphosphate; CK1; casein kinase 1; CK2; casein kinase 2; CTD; C-terminal domain; TTFL; transcriptional and translational feedback loop; GSK-3β; glycogen synthase kinase 3β; MEFs; mouse embryonic fibroblast cells; ConA; concanavalin A; LP
A screening assay for the identification of host cell requirements and antiviral targets for hepatitis D virus infection
Keywords: مهار کننده های کیناز; Hepatitis delta virus (HDV); Human kinome; Kinase inhibitors; Automated screen; AGC; named after protein kinases A, G, and C families; BET; bromo-and extra-terminal domain; CDK; cyclin-dependent kinase; CK-1; cell kinase 1; CLK; CDK-like kinase; Crk; CT10
Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells
Keywords: مهار کننده های کیناز; Granulosa cell tumor; Kinase inhibitors; Ovarian cancer; Screening strategies;
ReviewSurvival of patients with advanced metastatic melanoma: the impact of novel therapies-update 2017
Keywords: مهار کننده های کیناز; Melanoma; Therapy; Kinase inhibitors; Immune checkpoint blockers; Survival;
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma
Keywords: مهار کننده های کیناز; Pyrrolo-pyrimidines; Src; Glioblastoma; Kinase inhibitors; Small molecules;
Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors
Keywords: مهار کننده های کیناز; Kinase inhibitors; Cell cycle; Apoptosis; Anticancer activity; Furanone; Slow binding;
The mammalian STE20-like kinase 1 (MST1) is a substrate for the apoptosis inhibiting protein kinase CK2
Keywords: مهار کننده های کیناز; Proteolysis; Protein kinase; Phosphorylation; Kinase inhibitors; Caspase; Cleavage;
Furo[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents
Keywords: مهار کننده های کیناز; Kinase inhibitors; Furo[2,3-d]pyrimidine; Synthetic strategy; Anticancer
New treatment approaches in CLL: Challenges and opportunities in the elderly
Keywords: مهار کننده های کیناز; Chronic lymphocytic leukemia; Chemoimmunotherapy; Kinase inhibitors; BCL2 inhibitor;
Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure
Keywords: مهار کننده های کیناز; Pyrido[3,4-g]quinazoline; Kinase inhibitors; Ser/Thr kinases; CMGC family; CLK1 binding mode;
Los inhibidores de las proteínas-cinasas en enfermedades autoinmunes e inflamatorias: presente y futuro de nuevas dianas terapéuticas
Keywords: مهار کننده های کیناز; Proteínas-cinasas; Tirosinas-cinasas; Inhibidores de las tirosinas-cinasas; Vías de señalización intracelular; Autoinmunidad; Inflamación; TofacitinibProtein-kinase; Tyrosine-kinase; Kinase inhibitors; Intracellular signalling; Autoimmunity; Inflammation;
Protein-kinase Inhibitors: A New Treatment Pathway for Autoimmune and Inflammatory Diseases?
Keywords: مهار کننده های کیناز; Protein-kinase; Tyrosine-kinase; Kinase inhibitors; Intracellular signaling; Autoimmunity; Inflammation; TofacitinibProteínas-cinasas; Tirosinas-cinasas; Inhibidores de las tirosinas-cinasas; Vías de señalización intracelular; Autoinmunidad; Inflamación;
Interaction of new kinase inhibitors cabozantinib and tofacitinib with human serum alpha-1 acid glycoprotein. A comprehensive spectroscopic and molecular Docking approach
Keywords: مهار کننده های کیناز; AAG, human alpha 1 acid glycoprotein; CBZ, Cabozantinib; TFB, TofacitinibHuman Serum Alpha-1 acid glycoprotein; Kinase inhibitors; Fluorescence quenching; Circular dichroism spectroscopy; Molecular docking
Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors
Keywords: مهار کننده های کیناز; CLK1; DYRK1A; Kinase inhibitors; Imidazo[1,2-a]pyridines;
Identification of azepinone fused tetracyclic heterocycles as new chemotypes with protein kinase inhibitory activities
Keywords: مهار کننده های کیناز; Kinase inhibitors; Azepinone; Tetracyclic scaffolds; Heck coupling; TAK1 inhibitors;
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma
Keywords: مهار کننده های کیناز; PDK1 inhibitors; Kinase inhibitors; Oxindole derivatives; Pyridonyl derivatives; Glioblastoma; GBM stem cells; OXIDs; 2-oxindole derivatives; TBTU; N,N,Nâ²,Nâ²-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate; DIPEA; N,N-Diisopropylethylamine;
Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors
Keywords: مهار کننده های کیناز; Cyclin-dependent kinase 2; Kinase inhibitors; Anti-tumor agent; 1H-pyrrolo[2,3-b]pyridine; [3Â +Â 2] cycloaddition; 1,4-Triazole; 1,5-Triazole; 3D-QSAR CoMFA; CCR2; CC chemokine receptor 2; CCL2; CC chemokine ligand 2; CCR5; CC chemokine receptor 5;
Synthesis of antitumor 3,4,6,7-tetrahydro-2H-pyrimido[1,6-c]quinazolin-2-imine derivatives via reductive dearomatization-initiated intramolecular cyclization
Keywords: مهار کننده های کیناز; 3,4,6,7-Tetrahydro-2H-pyrimido[1,6-c]quinazolin-2-imine; N-fused heterocycles; Cyclization reaction; Antitumor agents; Kinase inhibitors;
Orally bioavailable Syk inhibitors with activity in a rat PK/PD model
Keywords: مهار کننده های کیناز; Spleen Tyrosine Kinase; Fostamatinib; BIIB-057; GS-9973; Kinase inhibitors;
Structure-based design of low-nanomolar PIM kinase inhibitors
Keywords: مهار کننده های کیناز; PIM; Kinase inhibitors; Rational design; De novo design; PIM inhibitors
Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors
Keywords: مهار کننده های کیناز; ATP; adenosine 5â²-triphosphate; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FC; flash chromatography; GIST; gastrointestinal stromal tumor; MAPK; mitogen activated protein kinase; PDGFR; platelet-derived growth factor receptor
Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents
Keywords: مهار کننده های کیناز; Kinase inhibitors; Thieno[2,3-d]pyrimidine; Synthetic strategy; SAR
Protein kinase CK2 is necessary for the adipogenic differentiation of human mesenchymal stem cells
Keywords: مهار کننده های کیناز; Stem cells; Protein kinase CK2; Adipogenic differentiation; Kinase inhibitors;
Synthesis and biological evaluation of 2,4-diaminopyrimidines as selective Aurora A kinase inhibitors
Keywords: مهار کننده های کیناز; Aurora kinase; Kinase inhibitors; Pyrimidine; Cell cycle;
Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor
Keywords: مهار کننده های کیناز; Insulin-like growth factor-1 receptor (IGF-IR); Anti-cancer; Kinase inhibitors; Pyrimidines; Pyrazoles
Synthesis and molecular modelling studies of 8-arylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors
Keywords: مهار کننده های کیناز; Microwave-assisted chemistry; Alzheimer disease; Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines; Kinase inhibitors
Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells
Keywords: مهار کننده های کیناز; Protein kinase CK2; Kinase inhibitors; HIF-1α; Murine xenograft;
CDK8 kinase—An emerging target in targeted cancer therapy
Keywords: مهار کننده های کیناز; CDK8 kinase; Cancer; Novel therapies; Kinase inhibitors; Transcription regulation