LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

► H2O2 enhances LRRK2 kinase activity and toxicity. ► H2O2 augments LRRK2-induced locomotor defects and dopamine neuron loss in flies. ► GW5074 reduces the combined toxicity of H2O2 and LRRK2 mutation. ► Curcumin inhibits LRRK2 kinase activity and rescues PD-like phenotypes in flies.